Moreover, the insulin levels showed a tendency to be positively correlated with body weight change (Week 8, r = 0.428 and P = 0.098, and Week 9, r = 0.466 and P = 0.069) in the OLZ-treated group, suggesting that the changes in body weight gain might be partially associated with OLZ-induced hyperinsulinemia and insulin resistance, whereas CLZ treatment indicated a lack of this correlation. The gene discussed is INS; the disease is Hyperinsulinemia.