After 5-week treatment, insulin levels showed a clear increase that reached significance at Weeks 5– 9 for the OLZ group compared with the control (all p < 0.05; Fig. 4B) or at Week 9 compared with the baseline (Week 0) of the OLZ group (Fig. 4E), following a continuous increase in HOMA-IR (to assess insulin resistance) which was consistent with insulin levels (Fig. 4C). The gene discussed is INS; the disease is Insulin resistance.