Amongst Myeloma XI trial patients, homozygous deletion of CDKN2C (1p32), BIRC2/BIRC3 (11q22) and amplification of CKS1B (1q21) and MYC (8q24) were the commonest focal homozygous copy number changes, which were seen at similar frequencies to those previously reported (Table 1).15 This evidence concerns the gene MYC and plasma cell myeloma.