Recently, activity of bcl-2 inhibitors has been reported in CCND1-driven t(11;14) MM, and CCND1-driven gain(11q25)-HRD may constitute another target group.36 We also found a high frequency of del(13q) in gain(1q)-HRD, in contrast to gain(11q25)-HRD. Here, BCL2 is linked to Miyoshi myopathy.