POMC and adrenal gland hyperfunction: Second-line treatment with paclitaxel was commenced, but recurrent hypercortisolism was evident by six months with a rise in morning cortisol to 722 mmol/L and ACTH to 19 pmol/L and 24-h urinary free cortisol to 2146 nmol/24 h (RR 35–285 nmol/day) requiring reinstitution of adrenal blockade.