Viral respiratory tract infections, especially rhinovirus infection, are the main triggers of asthma exacerbations.142, 143 Several,144, 145, 146 but not all,147, 148 studies have shown that bronchial epithelial cells from asthmatic donors respond abnormally to rhinovirus infection involving an insufficiency of IFN-β and IFN-λ. Here, IFNB1 is linked to asthma.