AIF1 and hypertrophic cardiomyopathy 1: In the CAA-associated CMH mouse model used for the pharmacological inhibition studies with cilostazol, the ICAM-1 and Iba-1 positive immunoreactive areas were significantly higher in the Tg mouse brains compared with the WT littermates, while increases in the GFAP positive immunoreactive area in the Tg mice reached statistical significance only in those mice treated with cilostazol (Fig. 8a–c).