Given this situation and the rapid development of regenerative medical therapy, many researchers have performed deep and fruitful analyses of AMD and ARMS2. A recent report using a bisretinoid N-retinylidine-N-ethanolamine (A2E)-stressed human induced pluripotent stem cell (iPSC) model of AMD indicates that ARMS2/HTRA1 compromises the superoxide dismutase 2 response, suggesting increased vulnerability to oxidative stress [12]. Here, HTRA1 is linked to age-related macular degeneration.