Moreover, paracrine effect was also found in heterografts of human ASCs in a rat MI model, which resulted in noticeable improvements in cardiac function and the prevention of myocardial remodeling via secretion of the proangiogenic factors VEGF, HGF, bFGF, nerve growth factor beta, and stromal cell-derived factor-1α [17]. This evidence concerns the gene VEGFA and myocardial infarction.