Dox treatment significantly reduced AOM-induced colon carcinogenesis in FVB/N mice (9.8 ± 0.97 vs. 15 ± 2.0 in multiplicity, P < 0.05), indicating that Dox treatment leading to suppression of SphK1 expression inhibits colon carcinogenesis. The gene discussed is SPHK1; the disease is infectious otitis media.