ABCC2 and Abnormal renal physiology: In another large study performed by Nishijima et al. in the same setting no association was observed between ABCC2 (−24C > T) and major renal outcome (>10 ml/min/1.73 m2 decrement in eGFR relative to baseline, >25% decrement in eGFR, and eGFR <60 ml/min/1.73 m2) related to TDF toxicities and the authors concluded that such SNPs are not to be considered a risk factor for clinical TDF-related renal dysfunction [18].