Therefore, SYNE1 gene mutations could cause EDMD4 [4] and spinocerebellar ataxia type 8 [5] theoretically, as well as myogenic arthrogryposis multiplex congenita with EDMD features [6] and intellectual disability with spastic paraplegia and axonal neuropathy [7]. This evidence concerns the gene SYNE1 and spinocerebellar ataxia type 8.