The proportion of BRAF mutation was higher in tumors located in the right colon (56.8% vs 23.9% with wild-type BRAF; P = 0.001), with an advanced tumor stage (T4, 29.5% vs 11.9%; P = 0.005), with lymph node metastasis (N2, 38.6% vs 20.5%; P = 0.015), and with lymphatic invasion (65.9% vs 44.0%; P = 0.007). The gene discussed is BRAF; the disease is metastatic malignant neoplasm in the lymph nodes.