Ten patients (congestive heart failure, n = 5; angina, n = 2; stroke n = 1; transient ischemic attack, n = 1; sudden death, n = 1) in the low-FGF21 group and 14 patients (congestive heart failure, n = 9; myocardial infarction, n = 2; stroke, n = 1; arterial/venous thrombotic episode, n = 1; one sudden death, n = 1) in the high-FGF21 group developed cardiovascular events. Here, FGF21 is linked to congestive heart failure.