MBNL1 is a key regulator of muscle, heart, and brain transcript alternative-splicing, including in some genes that have been associated with specific DM1 symptoms such as insulin receptor (IR) [6], cardiac troponin T (cTNT) [7], and muscle-specific chloride ion channel (CLCN1) [8]. Here, INSR is linked to myotonic dystrophy type 1.