Recently 2-deoxy-D-glucose modified poly (ethylene glycol)-co-poly(trimethylene carbonate) nanoparticles (DGlu-Np) were developed as a potential dual-targeted drug delivery system for enhancing the blood brain barrier penetration via Glut-mediated transcytosis and improving the drug accumulation in the glioma via GLUT-mediated endocytosis [41]. Here, SLC2A1 is linked to glioma.