PYDC2 and infection: By contrast, mice infected with Salmonella enterica serovar Typhimurium via the orogastric route (106 c.f.u.)had no reduction in bacterial burden and no alterations in a variety of relevant cytokine responses at 2 or 4 days post infection (Supplementary Fig. 6A–C), consistent with the lack of POP2 modulation of NLRC4 inflammasome responses seen in vitro.