In TCGA database, the highest mutation frequency for SPOP was 7.63% (38/498) in prostate cancer, ZNF148 11.25% (9/80) in uveal melanoma 14.3%) and EZH1 11.25% (9/80) in uveal melanoma (Supplementary Fig. 5 and Supplementary Table 1). This evidence concerns the gene EZH1 and Familial prostate cancer.