The formation of thyroid nodular structure in adenomatoid nodule is probably an early stimulus that causes enlargement of the thyroid, such as Iodine deficiency, nutritional goitrogens or autoimmunity13, followed by local proliferation of follicular epithelial cell due to somatic EZH1 mutations, a genetic path different from thyroid cancer. The gene discussed is EZH1; the disease is thyroid gland carcinoma.