ZA treatment upregulated ABCA1 expression only in cells with detectable ABCA1 under baseline conditions, such as the myeloma cell line SKMM1, primary multiple myeloma cells (CD138+ MM) and bone marrow stromal cells (BMSC) derived from multiple myeloma patients (Supplementary Fig. 3). This evidence concerns the gene ABCA1 and Miyoshi myopathy.