MDM2 and colorectal cancer: To identify lncRNAs regulated by p53 in multiple cell lines, we performed microarray analysis (Affymetrix HT2.0) from three colorectal cancer (CRC) cell lines (HCT116, RKO and SW48) following activation of p53 with Nutlin-3 (Figure 1—figure supplement 1A and Figure 1—figure supplement 1—source data 1), a pharmacological inhibitor of MDM2.