AIM2 and infection: AIM2 is a member of the interferon‐inducible PYHIN (PYRIN and HIN domain‐containing) family proteins (also known as p200‐family proteins) and serves as the front line of defense against pathogen infection via caspase‐1 activation (Chuong et al., 2016; Gray et al., 2016; Man and Kanneganti, 2015; Rommereim and Subramanian, 2015).