The egg‐protecting hemagglutinating protein from H. pomatia has been established as a tumor cell marker and a prognostic indicator of different human tumor cell lineages 63, and its hexameric structure 64 may give rise to speculation regarding an evolutionary relationship to the mammalian nonimmune or ancestral immunoglobulin M. These molluscan agglutinins are produced in the albumen gland (connected to the oviduct), and emerging from the coat proteins of fertilized eggs. Here, GOLPH3 is linked to neoplasm.