In several other tissues, age‐dependent imbalance between VEGF and ENDO leads to impaired angiogenesis as it has been observed in gastric mucosa 25, besides in prostate 26, in adipose tissue 27 and in retinal epithelium 28, in addition to pathological conditions such as systemic sclerosis 29, 30, intracranial atherosclerosis 31 or acromegaly 32. Here, MANEA is linked to systemic sclerosis.