HIV-infected subjects included in this analysis (Figure 1A and Supplementary Table 1), classified as hepatitis B vaccine (HBV) responders (n = 10) and non-responders (n = 10), were not statistically different in terms of, age, median CD4 count (median 600.5 vs 504), HIV viral RNA level (median log10 copies/mL, 1.69 vs 1.73), or duration of HIV infection (mean 40.0 months vs 43.1), but were mostly men (all non-responders and 7 responders, P = 0.2, Fisher's exact test). This evidence concerns the gene CD4 and HIV infectious disease.