By contrast to our results, however, several studies in human and animal models have reported that diet-induced obesity decreases the basal expression of striatal DA receptors D2R (Wang et al., 2009; Johnson and Kenny, 2010; Wang et al., 2011; Robinson et al., 2015; Friend et al., 2016). Here, DRD2 is linked to obesity due to melanocortin 4 receptor deficiency.