Additionally, rs10757278 has been shown to modulate the ANRIL bindingsite for the transcription factor STAT1, which in turn regulates ANRIL expression (9).Considering the role of STAT1 in shaping an immunosuppressive tumor microenvironment in breast cancer cells(10), disruption of ANRIL binding site for STAT1 by the rs10757278 allele may beinvolved in breast cancer pathogenesis. This evidence concerns the gene CDKN2B-AS1 and breast cancer.