Herein, we propose to investigate the expressions of <i>hsa-MIR-204</i>, runt-related transcription factor 2 (<i>RUNX2</i>), peroxisome proliferator-activated receptor gamma (<i>PPARγ</i>), and B-cell lymphoma 2 (<i>BCL2</i>) as factors involved in osteogenesis, adipogenesis, and MSC survival in BM-MSCs from MM patients and normal individuals.<h4>Materials and methods</h4>In this experimental study, we isolated MSCs from BM aspirates of MM patients and healthy donors. This evidence concerns the gene BCL2 and Miyoshi myopathy.