The functionof oncogenic fusion proteins like PML-RARα mayresult in decreased KLF5 expression since thesefusion proteins directly reduce the expression oftumor suppressors such as P21 (CDKN1A) (93).Hypermethylation detection at KLF5 locus canhelp identifying the appropriate patients for specifictherapy because demethylating agents such as 5-aza-2-deoxycytidine (Decitabine), reactivating KLF5expression, have been successful in some clinicaltrials in AML (Table 1) (90, 94). Here, CDKN1A is linked to acute myeloid leukemia.