Human chromodomain helicase DNA binding protein 5 (CHD5), Krüppel-like factor 2 (KLF), Retinoblastoma protein-interacting zinc finger 1 (RIZ), and IKAROS family zinc finger 1 (IKZF1) are among the genes that regulates gene transcription, and are inactivated in acute lymphoid leukemia (ALL). The gene discussed is KLF2; the disease is acute lymphoblastic leukemia.