Low levels of miR-15a and miR-16 in combination with selective loss of miR-29b may contribute to the pathobiology of CLL.MiR-29b is another miR, which is decreased in CLL.MiR-29b acts as a tumor suppressor targeting ,Mcl-1, SP1, DNMT3a, DNMTb, Tcl-1 and Cdk6 in CLL (41). Here, SP1 is linked to B-cell chronic lymphocytic leukemia.