VHL and hereditary clear cell renal cell carcinoma: Von Hippel–Lindau (VHL) is a prominent tumor suppressor and is expressed as p19-VHL and p30-VHL isoforms.11 VHL has also been shown to play an oncogenic role by regulating dynamin-dependent endocytosis through nm2312–14 and inhibiting apoptosis in response to multiple signals.15,16 VHL also regulates the expression of VEGF and VEGFR2 (drivers of the blebbishield emergency program1,2,5), through multiple mechanisms in renal cell carcinoma, for which VHL is an established cause.17–19 However, the reason why VHL plays oncogenic as well as tumor suppressor roles is poorly understood.