VHL interacts with transcriptional elongation factors elongin-B and elongin-C24,25,26 to form a complex, and to act as a tumor suppressor.27 Since VHL-regulated genes (could be direct or indirect targets) were identified previously,28 we examined VHL-regulated gene expression (137 genes) in the blebbishield emergency program using our microarray transcriptome profiling data to get insight into the functional targets of VHL during blebbishield formation and transformation from blebbishields. Here, VHL is linked to neoplasm.