VHL, a prominent tumor suppressor, often gets inactivated in renal cell carcinoma.11 VHL has two isoforms, p19-VHL and p30-VHL, generated by alternative initiation codons.11,40–42 We for the first time demonstrated an oncogenic role for p19-VHL isoform by showing its ability to override apoptosis through its oligomeric states and demonstrated a tumor suppressor role for p30-VHL by showing that its expression inhibits transformation phase of blebbishield emergency program. Here, VHL is linked to hereditary clear cell renal cell carcinoma.