Interestingly, while gene set enrichment (GSEA) analysis of the same microarray data set with GSEA algorithm detected that gene sets related with proteasome machinery, MYC upregulation and ribosomes components were associated with a high risk of oral cancer development,22 we were unable to stratify patients with leukoplakia according to their progression status based on our analysis. The gene discussed is MYC; the disease is lip and oral cavity carcinoma.