Linc-ROR was first identified as an endogenous sponge inhibiting the differentiation of ESC by targeting miR-145.12 Recent studies revealed a tumor-promoting role of linc-ROR in breast cancer,15 endometrial cancer.25 Most recently, Takahashi et al.14 revealed that linc-ROR regulates hypoxia signaling pathways by inhibiting the function of miR-145 in hepatic cancer cells. The gene discussed is LINC-ROR; the disease is liver cancer.