Western blotting indicated CAML protein reduction in tumors due to tamoxifen treatment (Figure 3c), similar to that previously demonstrated in tissues examined for Cre-ER;Camlfl/fl mice treated with tamoxifen.14,17 Kaplan–Meier survival curves plotted for tumor end points requiring killing showed a dramatic difference in survival with the vast majority of tamoxifen-treated mice alive at the conclusion of the experiment (P<0.01; Figure 3d). The gene discussed is ESR1; the disease is neoplasm.