To investigate the function of CAML in c-Myc-driven B-cell lymphomas, we generated Eμ-Myc transgenic mice carrying floxed alleles of Caml and the Cre-ERT2 transgene, thus allowing tamoxifen-inducible deletion of Caml. 12,13 Spleens collected from mice exhibiting signs of lymphoma (for example, tumor masses and hunched back) were used to establish cell lines. This evidence concerns the gene MYC and B-cell non-Hodgkin lymphoma.