MAPK3 and lymphoma: To investigate the function of CAML in c-Myc-driven B-cell lymphomas, we generated Eμ-Myc transgenic mice carrying floxed alleles of Caml and the Cre-ERT2 transgene, thus allowing tamoxifen-inducible deletion of Caml. 12,13 Spleens collected from mice exhibiting signs of lymphoma (for example, tumor masses and hunched back) were used to establish cell lines.