Our present study is the first to explore CAML function in a cancer model, and is consistent with previous findings in stimulated B and T lymphocytes, and thymocytes.13,14,15,17 Under conditional Caml deletion, these cell types showed increased apoptosis when they were activated by mitogens, similar to our results in Eμ-Myc lymphomas. The gene discussed is CAMLG; the disease is lymphoma.