Depletion of ileal LP CD4+ T-cells was only observed in both the second macaque sacrificed at D65 pi and the macaque with AIDS-related symptoms (82 and 76% decrease compared to mean values in macaques sampled at baseline, Figure 5A; right panel), consistent with the depletion of gut CD4+ T-cells that has been largely described in chronically infected macaques and humans. The gene discussed is CD4; the disease is AIDS.