Moreover, nuclear genome mutations that cause imbalances in mitochondrial functions (e.g., gene TYMP mutation that results in the patients with mitochondrial neuro gastro intestinal encephalomyopathy) or disorders in the long-chain fatty acid oxidation in the mitochondrion (e.g., carnitine palmitoyltransferase 1A deficiency biallelic pathogenic variants) are more prone to bacterial infection than general population (Garone et al., 2011; Gessner et al., 2013). The gene discussed is TYMP; the disease is bacterial infectious disease.