APC and colorectal carcinoma: In this scenario, reactivation of embryonic signaling pathways (possibly via aberrant paracrine interactions with a pericryptal myofibroblast “stem cell niche”) (Vermeulen et al., 2010) and CRC upregulation of Wnt signaling, in conjunction with the loss of gatekeeper genes (SFRP, APC, DKK, etc.)upregulate EMT and other promalignant processes (Aguilera et al., 2006; Silva et al., 2014).