Non-compliance with screening for these at-risk individuals remains approximately 25% (Wong et al., 2016), and 5–10% of CRC cases are due to hereditary conditions, the majority of which include mutations in the tumor suppressor gene APC. Consequently, while optimism persists for increased compliance with preventative screening, possibly due to healthcare reforms to alleviate cost, it appears a large number of advanced cases will remain (Siegel et al., 2014). The gene discussed is APC; the disease is colorectal carcinoma.