These results suggest that the down-regulation of BDNF, TrkB and NR2B associated with depression-induced reduction of GR nuclear translocation may contribute to the attenuation of neuropathic pain behavior in depressed SNL rats and that spinal BDNF-TrkB signaling is possibly modulated by GR activation following intrathecal injection of Dex in rats with neuropathic pain. This evidence concerns the gene GRIN2B and major depressive disorder.