When binding with glucocorticoids, GRs translocate from cytoplasm into nucleus to mediate transcriptional activation/repression of target genes, participating in the initiation and development of various physiological and pathological processes, including major depression and neuropathic pain (Mao, 2005; Kadmiel and Cidlowski, 2013; Madalena and Lerch, 2016). This evidence concerns the gene BCL2A1 and major depressive disorder.