It has been demonstrated that increased GR activity leading to activation of the NR1/NR2 subunits of NMDA receptor in spinal dorsal horn contributed to neuropathic pain in rats with peripheral nerve injury (Wang et al., 2005; Alexander et al., 2009; Le Coz et al., 2014; Zhang et al., 2014). The gene discussed is NR3C1; the disease is peripheral nerve injury.