In studies of the neural mechanisms of chronic pathological pain, researchers have found that enhanced spinal GRs contributed to central sensitization and allodynia/hyperalgesia of neuropathic pain induced by peripheral nerve injury, and GR antagonists could block the mechanical allodynia and/or thermal hyperalgesia of chronic inflammatory pain and neuropathic pain (Takasaki et al., 2005; Wang et al., 2005; Alexander et al., 2009; Le Coz et al., 2014; Zhang et al., 2014; Madalena and Lerch, 2016). The gene discussed is NR3C1; the disease is peripheral nerve injury.