Interestingly, our recent findings represent cellular QC capacity of MGRN1 under various proteotoxic stress conditions and establish a neurobiological role of MGRN1 against toxic misfolded mutants of SOD1 and expanded polyglutamine proteins, which are involved in causing ALS and polyglutamine diseases, respectively (Chhangani et al., 2014a, 2016). Here, MGRN1 is linked to amyotrophic lateral sclerosis.