The emerging function of E6-AP were discovered later and is associated with its E3 ubiquitin ligase like capabilities, through which it can play a very important neuroprotective role in cellular QC mechanisms and its functional presence is involved in different neurodegenerative diseases through clearance of several misfolded proteins (Upadhyay et al., 2015a). This evidence concerns the gene UBE3A and neurodegenerative disease.