E3 ubiquitin ligase E6-AP is encoded by UBE3A gene; mutations and genetic imprinting in this gene result in Angelman syndrome (AS), which can be described by symptoms like frequent laughter, tremor, ataxia, abnormal gait, seizures, and neurological impairments (Kishino et al., 1997). The gene discussed is UBE3A; the disease is Angelman syndrome.