For example, aggregation of expanded polyglutamine repeat proteins such as those implicated in Huntington's disease and spinocerebellar ataxia can inhibit clathrin-mediated endocytosis by competitive binding and sequestration of Hsc70, and decreased Hsc70 expression (Yamanaka et al., 2008; Yu et al., 2014). Here, HSPA8 is linked to juvenile Huntington disease.