In the present study, using experimental autoimmune encephalomyelitis (EAE) as an animal model for MS, we found a link between the expression pattern of key molecules involved in the biosynthesis (HMGCR), recycling (ApoE) and degradation (CYP46A1) of cholesterol and the progression and resolution of EAE in the rat spinal cord. Here, CYP46A1 is linked to myeloid sarcoma.