DUOX2 expression, unlike that of the DUOX1 homolog, is associated with progression of pancreatic cancer; the pro-inflammatory cytokine IFN-γ triggers Stat1-mediated DUOX2/DUOXA2 up-regulation in pancreatic cancer cell lines, contributing to increased intra- and extracellular ROS production [12]. This evidence concerns the gene IFNG and familial pancreatic carcinoma.