The association of SNVs in the LPL gene with the biochemical phenotype of hypercholesterolemia, primarily the HDL-C level was observed in many GWAS done in different population groups worldwide, with several SNVs having replicated evidence of association (e.g. rs12678919, rs328, rs10503669, rs17411031, rs10096633, rs17482753, rs2083637) [14, 16, 17, 19, 20, 22–26, 37, 38, 91–94]. The gene discussed is LPL; the disease is Hypercholesterolemia.