Few mutations in the APOB gene causing defective binding of LDL to LDL-receptor and causing FH have been described, and p.3527 (earlier reported as p.3500) was described as the ‘mutation hotspot’ of APOB gene because genetic mutations in majority of patients with FH due to defective apoB were observed at this location [13]. This evidence concerns the gene APOB and familial hyperaldosteronism.