APOA1 and Hepatic steatosis: For example, it has been shown that apoA-I increases mitochondrial biogenesis through AMP-activated protein kinase (AMPK) [35], and fasting-induced hepatic steatosis can be exacerbated by the impairment of AMPK [36] and rescued by AMPK activator [37], suggesting multiple functions of apoA-I in NASH.