ACTA1 and polyostotic fibrous dysplasia: Both NAC (an antioxidant for intracellular ROS) and Mito-TEMPO (a specific antioxidant for mitochondrial ROS) efficiently inhibited myofibroblast differentiation of type I collagen and αSMA expression caused by PARK2 knockdown (Fig. 4c, d), suggesting that the anti-oxidative properties of PFD result mainly from regulation of mitophagy.