The anti-fibrotic properties of PFD during insufficient mitophagy of PARK2 knockdown were mainly attributed to anti-oxidative effects, resulting in attenuation of PDGFR-PI3K-AKT signaling, suggesting PARK2-mediated mitophagy is not indispensable for anti-oxidative properties of PFD. Here, AKT1 is linked to polyostotic fibrous dysplasia.