GRIN2B and major depressive disorder: This hypothesis is at least partly supported both by clinical findings showing that another NR2B subunit-selective NMDAR antagonist, CP-101,606 (traxoprodil), also produced dissociative effects on top of antidepressant actions in patients with MDD (Preskorn et al. 2008) and by studies on KET which revealed that the degree of dissociative symptoms experienced during KET infusions robustly correlated with the degree of reported depression rating scale improvement (Luckenbaugh et al. 2014).