The determination of urinary expression of VDBP and RBP can provide important information, because both of those proteins can be used as markers of early kidney injury (stage 1 or 2 CKD), whereas low urinary expression of THP can be associated with advanced‐stage renal disease (stage 3 or 4 CKD) and serve as a marker of CKD progression in dogs. This evidence concerns the gene GC and chronic kidney disease.