TNF and cancer: The HRs of the CC & CT genotypes of TNF-α 1031T/C for total death and incidence of cancer and atherosclerosis-related diseases with HTLV-I seem to be higher than those of the TT genotype, and the interaction between TNF-α 1031T/C polymorphism and HTLV-I for incidence of atherosclerosis-related diseases was statistically significant (p = 0.020; Table 3).