Studies utilizing comparative genomic hybridization (CGH) found recurrent 13q14 amplification, of which CUL4A may be a target, in various types of tumors, including esophageal squamous cell carcinoma [22], adrenocortical carcinoma [23], hepatocellular carcinoma [5], and childhood medulloblastoma [24]. This evidence concerns the gene CUL4A and esophageal squamous cell carcinoma.