Evidence for this was provided by the study of Wang et al. who reported that CUL4A transcriptionally activates ZEB1 (Zinc finger E-box-binding homeobox 1) expression via increasing the levels of H3K4 (histone H3 lysine 4) trimethylation [9], resulting in the subsequent decrease in the levels of epithelial markers (E-cadherin and α-catenin) and the increase in the abundance of mesenchymal markers (N-cadherin, fibronectin, and vimentin) in tumor cells, which are characteristic of EMT. Here, CUL4A is linked to neoplasm.