The tumor samples with Y622* and Q625* mutations exhibited G1 phase arrest with high S phase DNA (p value = 0.071) leading to loss of the role of APC in mitosis and chromosome stability [32].Most of the gastric cancer samples showed diploidy, except in samples containing 622 and 625 codon change where aneuploidy resulted in less DNA content in G2/M phase and high DNA content in S phase (Fig. 4). Here, APC is linked to gastric cancer.