Previous studies have shown that activation of the Gαh/PLC-δ1 signaling axis by several G protein-coupled receptors (e.g., α1B-adrenergic [5], oxytocin [27], and FSH [6] receptors) induces fluctuations in the levels of intracellular Ca2+ and promotes the metastatic evolution of TNBC cells by modulating their epithelial-to-mesenchymal transition (EMT), which is known as the initial step of cancer metastasis [28, 29]. This evidence concerns the gene GDA and cancer.