However, the most prevalent BRCA2 alleles that confer a clinically significant risk of cancer susceptibility encode nonsense or frameshift mutations, which prematurely truncate the BRCA2 protein (Rebbeck et al., 2015) (Breast Cancer Information Core [BIC] database, https://research.nhgri.nih.gov/bic/). The gene discussed is BRCA2; the disease is cancer.