CASP3 and neuroblastoma: Interestingly, the GSK-3 inhibitors LiCl and SB216763 attenuated caspase 3 and PARP cleavage induced by arsenite (NaAsO2) in SH-SY5Y neuroblastoma cells, indicating that active GSK-3 is required for arsenite induced apoptotic cell death in these cells [49].