Therefore, we conducted stratified analysis on the data according to age, gender, tumor site, tumor size, tumor node metastasis (TNM) stage, presence of hypertension, diabetes mellitus, and levels of body Therefore, we conducted a stratified analysis on data according to age, gender, tumor site, tumor size, tumor-node-metastasis (TNM) stage, presence of hypertension, diabetes mellitus, and levels of body mass index (BMI) to determine whether the TNF-α-308 G>A polymorphism was associated with CRC incidence in specific subsets of the study population. The gene discussed is TNF; the disease is hypertensive disorder.