TNF and metastatic malignant neoplasm in the lymph nodes: To understand the association between TNF-α -308 G>A polymorphism and clinical features of CRC, logistic regression analysis was used to evaluate the correlations between TNF-α-308 G>A polymorphism and clinical characteristics (gender, age at diagnosis, BMI, tumor stage, tumor size, lymph-node metastasis, distant metastasis, history of polyp, and family history of cancer by CRC tumor-site classification), as shown in Table 4.